Beacon Reconstruction Attack: Reconstruction of genomes in genomic data-sharing beacons using summary statistics.

Abstract excerpt

MOTIVATION: Genomic data-sharing beacon protocol, developed by the Global Alliance for Genomics and Health, offers a privacy-preserving mechanism for querying genomic datasets while restricting direct data access. Despite their design, beacons remain vulnerable to privacy attacks. This study introduces a novel privacy vulnerability of the protocol: one can reconstruct large portions of the genomes of all beacon...

Topics

• Genomics
• Humans
• Algorithms
• Polymorphism, Single Nucleotide
• Information Dissemination
• Gene Frequency