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Dengue and Zika RNA-RNA interactomes reveal pro- and anti-viral RNA in human cells

5 Dec 2023

Abstract excerpt

BACKGROUND: Identifying host factors is key to understanding RNA virus pathogenicity. Besides proteins, RNAs can interact with virus genomes to impact replication. RESULTS: Here, we use proximity ligation sequencing to identify virus-host RNA interactions for four strains of Zika virus (ZIKV) and one strain of dengue virus (DENV-1) in human cells. We find hundreds of coding and non-coding RNAs that bind to DENV...

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PMID: 38053173
DOI: 10.1186/s13059-023-03110-9

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