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Article

Estimating overdiagnosis in giant cell arteritis diagnostic pathways using genetic data: genetic association study.

Rheumatology (Oxford, England) - 1 Aug 2024

Chatzigeorgiou Charikleia, Barrett Jennifer H, Martin Javier, Morgan Ann W, Mackie Sarah L

Abstract excerpt

OBJECTIVES: GCA can be confirmed by temporal artery biopsy (TAB) but false negatives can occur. GCA may be overdiagnosed in TAB-negative cases, or if neither TAB nor imaging is done. We used HLA genetic association of TAB-positive GCA as an 'unbiased umpire' test to estimate historic overdiagnosis of GCA. METHODS: Patients diagnosed with GCA between 1990 and 2014 were genotyped. During this era, vascular imaging...

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Identifiers

PMID: 38048604
DOI: 10.1093/rheumatology/kead643
PMCID: PMC11292050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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