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Article

Amino acid substitution L232F in non-structural protein 6 identified as a possible human-adaptive mutation in clade B MERS coronaviruses.

Journal of virology - 21 Dec 2023

So Ray T Y, Chu Daniel K W, Hui Kenrie P Y, Mok Chris K P, Shum Marcus H H, Sanyal Sumana, Nicholls John M, Ho John C W, Cheung Man-Chun, Ng Ka-Chun, Yeung Hin-Wo, Chan Michael C W, Poon Leo L M, Zhao Jincun, Lam Tommy T Y, Peiris Malik

Abstract excerpt

IMPORTANCE: Viral host adaptation plays an important role in inter-species transmission of coronaviruses and influenza viruses. Multiple human-adaptive mutations have been identified in influenza viruses but not so far in MERS-CoV that circulates widely in dromedary camels in the Arabian Peninsula leading to zoonotic transmission. Here, we analyzed clade B MERS-CoV sequences and identified an amino acid...

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Identifiers

PMID: 38038429
DOI: 10.1128/jvi.01369-23
PMCID: PMC10734512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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