Article
Analysis of homozygous allele mismatches in paternity tests with massively parallel sequencing.
Electrophoresis - 1 Mar 2024
Ren He, Zhang Jiarong, Yang Tingting, Zhang Xiaomeng, Liu Jinding, Chen Chong, Shi Yan, Chen Ying, Jia Li, Simayijiang Halimureti, Yan Jiangwei
Abstract excerpt
In paternity testing, short tandem repeats (STRs) allele mismatches are often detected. Nowadays, polymerase chain reaction- and capillary electrophoresis (CE)-based STR genotyping is the most commonly used method to distinguish alleles based on their length. However, it could not detect alleles of the same size with sequence differences. Massively parallel sequencing (MPS) can determine not only allele sizes but...
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