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Article

KIF5A and ALS: a clinical and genetic description of a case series and review of literature.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 28 Feb 2026

D'Amico Anna, Cucunato Roberta, Schirò Giuseppe, Salemi Giuseppe, Ragonese Paolo, La Bella Vincenzo, Aridon Paolo, D'Amelio Marco

Abstract excerpt

Approximately 10% of ALS (amyotrophic lateral sclerosis) cases show a family history, and the remaining 90% are sporadic. In 2018, through genome sequencing using two independent approaches, KIF5A was described as a novel ALS-associated gene. To describe clinical and genetic characteristics of a series of patients with motor neuron disease (MND), diagnosed at University Hospital of Palermo, carrying KIF5A...

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Identifiers

PMID: 41760955
DOI: 10.1007/s10072-026-08885-w
PMCID: PMC12948853

Genes

KIF5A
FUS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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