Article
The Genetic Drivers of Juvenile, Young, and Early-Onset Parkinson's Disease in India.
Movement disorders : official journal of the Movement Disorder Society - 1 Feb 2024
Andrews Shan V, Kukkle Prashanth L, Menon Ramesh, Geetha Thenral S, Goyal Vinay, Kandadai Rukmini Mridula, Kumar Hrishikesh, Borgohain Rupam, Mukherjee Adreesh, Wadia Pettarusp M, Yadav Ravi, Desai Soaham, Kumar Niraj, Joshi Deepika, Murugan Sakthivel, Biswas Atanu, Pal Pramod K, Oliver Merina, Nair Sandhya, Kayalvizhi Anbu, Samson Praveena L, Deshmukh Manjari, Bassi Akshi, Sandeep Charugulla, Mandloi Nitin, Davis Oliver B, Roberts Melissa A, Leto Dara E, Henry Anastasia G, Di Paolo Gilbert, Muthane Uday, Das Shymal K, Peterson Andrew S, Sandmann Thomas, Gupta Ravi, Ramprasad Vedam L
Abstract excerpt
BACKGROUND: Recent studies have advanced our understanding of the genetic drivers of Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and the latest PD genome-wide association study (GWAS) identified 90 independent risk loci. However, there remains a gap in our understanding of PD genetics outside of the European populations in which the vast majority of these studies...
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