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Article

Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice.

Nature neuroscience - 1 Jan 2024

Li Wei-Ke, Zhang Shu-Qian, Peng Wan-Ling, Shi Yu-Han, Yuan Bo, Yuan Yi-Ting, Xue Zhen-Yu, Wang Jin-Cheng, Han Wen-Jian, Chen Zhi-Fang, Shan Shi-Fang, Xue Bi-Qing, Chen Jin-Long, Zhang Cheng, Zhu Shu-Jia, Tai Yi-Lin, Cheng Tian-Lin, Qiu Zi-Long

Abstract excerpt

Whole-brain genome editing to correct single-base mutations and reduce or reverse behavioral changes in animal models of autism spectrum disorder (ASD) has not yet been achieved. We developed an apolipoprotein B messenger RNA-editing enzyme, catalytic polypeptide-embedded cytosine base editor (AeCBE) system for converting C·G to T·A base pairs. We demonstrate its effectiveness by targeting AeCBE to an...

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PMID: 38012399
DOI: 10.1038/s41593-023-01499-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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