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Article

Increased Ubqln2 expression causes neuron death in transgenic rats.

Journal of neurochemistry - 1 Oct 2016

Huang Bo, Wu Qinxue, Zhou Hongxia, Huang Cao, Xia Xu-Gang

Abstract excerpt

Pathogenic mutation of ubiquilin 2 (UBQLN2) causes neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. How UBQLN2 mutations cause the diseases is not clear. While over-expression of UBQLN2 with pathogenic mutation causes neuron death in rodent models, deletion of the Ubqln2 in rats has no effect on neuronal function. Previous findings in animal models suggest that UBQLN2...

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Source

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Identifiers

PMID: 27456931
DOI: 10.1111/jnc.13748
PMCID: PMC5117623

Genes

UBQLN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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