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Regulation and distribution of European sea bass perforins point to their role in the adaptive cytotoxic response against NNV

23 Nov 2023

Abstract excerpt

Cell-mediated cytotoxicity is a complex immune mechanism that involves the release of several killing molecules, being perforin (PRF) one of the most important effector players. Perforin is synthesized by T lymphocytes and natural killer cells in mammals and responsible for the formation of pores on the target cell membrane during the killing process. Although perforin has been extensively studied in higher...

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PMID: 38000653
DOI: 10.1016/j.fsi.2023.109244

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