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Genomic and Transcriptomic Landscape of Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma: A Multicenter Study.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2025

Li Yan, Weng Ze-Lin, Fei Han-Xiao, Li Hai-Feng, Liu Yi-Na, Zhang Le-Le, Zhang Qiong, Weng Xin, Wang Yuan-Yuan, Huang Wen-Yong, Cao Zhi-Xing, Yang Kai-Yan, Chen Xi-Liang, Gao Jie, Yang Wen-Sheng, Liu Fang, Yong Juan-Juan, Yun Jing-Ping, Zhang Hua, Huang Yu-Hua

Abstract excerpt

Epstein-Barr virus (EBV)-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) is a rare indolent malignant neoplasm, which occurs almost exclusively in the liver or spleen and may arise from a common EBV-infected mesenchymal cell that differentiates along the follicular or fibroblastic dendritic cell pathway. Despite its rarity, it presents a pressing need for an improved understanding of its...

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PMID: 40784486
DOI: 10.1016/j.modpat.2025.100864

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