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Article

Ceftriaxone exerts antitumor effects in MYCN ‐driven retinoblastoma and neuroblastoma by targeting DDX3X for translation repression

17 Nov 2023

Abstract excerpt

MYCN proto-oncogene, bHLH transcription factor (MYCN) amplification is associated with aggressive retinoblastoma (RB) and neuroblastoma (NB) cancer recurrence that is resistant to chemotherapies. Therefore, there is an urgent need to identify new therapeutic tools. This study aimed to evaluate the potential repurposing of ceftriaxone for the treatment of MYCN-amplified RB and NB, based on the clinical...

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PMID: 37975412
DOI: 10.1002/1878-0261.13553

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