Article
Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries.
eLife - 17 Oct 2022
Li Xinxuan, Zhou Yajing, Yuan Shuai, Zhou Xuan, Wang Lijuan, Sun Jing, Yu Lili, Zhu Jinghan, Zhang Han, Yang Nan, Dai Shuhui, Song Peige, Larsson Susanna C, Theodoratou Evropi, Zhu Yimin, Li Xue
Abstract excerpt
Background: Epidemiological studies observed gender differences in COVID-19 outcomes, however, whether sex hormone plays a causal in COVID-19 risk remains unclear. This study aimed to examine associations of sex hormone, sex hormones-binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), and COVID-19 risk. Methods: Two-sample Mendelian randomization (TSMR) study was performed to explore the causal...
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