Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variations in AAK1 and ADAM17 associated with circulatory cytokines changes influence COVID-19 susceptibility and severity.

Human genomics - 27 Feb 2026

Bouzid Amal, Elemam Noha M, Alsafar Habiba, Venkatachalam Thenmozhi, Eldoahji Leen, Halabi Nour, Saleh Mohamed A, Talaat Iman M, Taneera Jalal, Sulaiman Nabil, Maghazachi Azzam A, Hamid Qutayba, Hamoudi Rifat, Saber-Ayad Maha

Abstract excerpt

BACKGROUND: The interplay between genetic factors and COVID-19 susceptibility and severity underscores the critical roles of genetic variations in the responses to the virus. Specifically, genetic variations in genes such as AAK1 and ADAM17 may influence the molecular pathways that determine how the virus enters cells and how the immune system responds, thereby affecting disease outcomes. Identifying these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM17 Protein
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COVID-19

Share to Cytokines

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to SARS-CoV-2

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 41761307
DOI: 10.1186/s40246-026-00928-9
PMCID: PMC13049976

Genes

AAK1
ADAM17
CD209
CD40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variations in AAK1 and ADAM17 associated with circulatory cytokines changes influence COVID-19 susceptibility and severity.PMID 41761307Read ↗

Circulating ADAM17 is associated with COVID-19 severitySemantic proximity Read ↗

Genetic Predisposition to Elevated Levels of Circulating ADAM17 Is Associated with the Risk of Severe COVID-19.Semantic proximity Read ↗

Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in VietnameseSemantic proximity Read ↗

Host genetic factors determining COVID-19 susceptibility and severity.Semantic proximity Read ↗

Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis.Semantic proximity Read ↗

Genetics Insight for COVID-19 Susceptibility and Severity: A Review.Semantic proximity Read ↗

Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression.Semantic proximity Read ↗

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalizationSemantic proximity Read ↗

IDENTIFICATION OF HUMAN GENETIC VARIANTS MODULATING THE COURSE OF COVID-19 INFECTIONSemantic proximity Read ↗

The role of inflammatory gene polymorphisms in severe COVID-19: a review.Semantic proximity Read ↗

The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature.Semantic proximity Read ↗

Genes Polymorphisms and Their Association with COVID-19 Severity in ChildrenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.