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Article

Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity

13 Nov 2023

Abstract excerpt

Abstract Late-life-initiated dietary interventions show limited efficacy in extending longevity or mitigating frailty, yet the underlying causes remain unclear. Here we studied the age-related fasting response of the short-lived killifish Nothobranchius furzeri. Transcriptomic analysis uncovered the existence of a fasting-like transcriptional program in the adipose tissue of old fish that overrides the feeding...

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PMID: 37957359
DOI: 10.1038/s43587-023-00521-y

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