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Article

Significance of micro-EGFR T790M mutations on EGFR-tyrosine kinase inhibitor efficacy in non-small cell lung cancer.

Scientific reports - 13 Nov 2023

Masuda Takeshi, Miura Satoru, Sato Yuki, Tachihara Motoko, Bessho Akihiro, Nakamura Atsushi, Miyawaki Taichi, Yoshimine Kohei, Mori Masahide, Shiraishi Hideaki, Hamai Kosuke, Haratani Koji, Maeda Sumiko, Tabata Eriko, Kitagawa Chiyoe, Tanizaki Junko, Imai Takumi, Nogami Shohei, Yamamoto Nobuyuki, Nakagawa Kazuhiko, Hattori Noboru

Abstract excerpt

Small amounts of epidermal growth factor receptor (EGFR) T790M mutation (micro-T790M), which is detected using droplet digital PCR (ddPCR) but not conventional PCR, in formalin-fixed and paraffin-embedded (FFPE) samples have been investigated as a predictive factor for the efficacy of EGFR-tyrosine kinase inhibitors (TKIs). However, the predictive value of micro-T790M remains controversial, possibly owing to the...

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Identifiers

PMID: 37957228
DOI: 10.1038/s41598-023-45337-3
PMCID: PMC10643699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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