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Article

PARP inhibitors combined with radiotherapy: are we ready?

26 Oct 2023

Abstract excerpt

PARP was an enzyme found in the nucleus of eukaryotic cells that played a crucial role in repairing damaged DNA. Recently, PARP inhibitors have demonstrated great potential in cancer treatment. Thus, the FDA has approved several small-molecule PARP inhibitors for cancer maintenance therapy. The combination of PARP inhibitors and radiotherapy relies on synthetic lethality, taking advantage of the flaws in DNA...

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PMID: 37954854
DOI: 10.3389/fphar.2023.1234973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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