Article
Mechanisms of disturbance of the contractile function of slow skeletal muscles induced by myopathic mutations in the tropomyosin TPM3 gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2020
Matyushenko Alexander M, Nefedova Victoria V, Shchepkin Daniil V, Kopylova Galina V, Berg Valentina Y, Pivovarova Anastasia V, Kleymenov Sergey Y, Bershitsky Sergey Y, Levitsky Dmitrii I
Abstract excerpt
Several congenital myopathies of slow skeletal muscles are associated with mutations in the tropomyosin (Tpm) TPM3 gene. Tropomyosin is an actin-binding protein that plays a crucial role in the regulation of muscle contraction. Two Tpm isoforms, γ (Tpm3.12) and β (Tpm2.2) are expressed in human slow skeletal muscles forming γγ-homodimers and γβ-heterodimers of Tpm molecules. We applied various methods to...
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