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Article

Molecular mechanisms of AMPK/YAP/NLRP3 signaling pathway affecting the occurrence and development of ankylosing spondylitis

4 Nov 2023

Abstract excerpt

BACKGROUND: Investigate the AMPK (protein kinase AMP-activated catalytic subunit alpha 1)/YAP (Yes1 associated transcriptional regulator)/NLRP3 (NLR family pyrin domain containing 3) signaling pathway's role in ankylosing spondylitis (AS) development using public database analysis, in vitro and in vivo experiments. METHODS: Retrieve AS dataset, analyze differential gene expression in R, conduct functional...

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PMID: 37925428
DOI: 10.1186/s13018-023-04200-x

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