Estimating microhaplotype allele frequencies from low-coverage or pooled sequencing data.

Abstract excerpt

BACKGROUND: Microhaplotypes have the potential to be more cost-effective than SNPs for applications that require genetic panels of highly variable loci. However, development of microhaplotype panels is hindered by a lack of methods for estimating microhaplotype allele frequency from low-coverage whole genome sequencing or pooled sequencing (pool-seq) data. RESULTS: We developed new methods for estimating...

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