Article
Genomic stability of self-inactivating rabies.
eLife - 3 Nov 2023
Ciabatti Ernesto, González-Rueda Ana, de Malmazet Daniel, Lee Hassal, Morgese Fabio, Tripodi Marco
Abstract excerpt
Transsynaptic viral vectors provide means to gain genetic access to neurons based on synaptic connectivity and are essential tools for the dissection of neural circuit function. Among them, the retrograde monosynaptic ΔG-Rabies has been widely used in neuroscience research. A recently developed engineered version of the ΔG-Rabies, the non-toxic self-inactivating (SiR) virus, allows the long term genetic...
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