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High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Rabies Virus Infection.

Stem cells (Dayton, Ohio) - 1 Aug 2015

Wallis Deeann, Loesch Kimberly, Galaviz Stacy, Sun Qingan, DeJesus Michael, Ioerger Thomas, Sacchettini James C

Abstract excerpt

We used a genomic library of mutant murine embryonic stem cells (ESCs) and report the methodology required to simultaneously culture, differentiate, and screen more than 3,200 heterozygous mutant clones to identify host-based genes involved in both sensitivity and resistance to rabies virus infection. Established neuronal differentiation protocols were miniaturized such that many clones could be handled...

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PMID: 25752821
DOI: 10.1002/stem.1983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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