Genetic study of early-onset Parkinson's disease in the Malaysian population.

doi:10.1016/j.parkreldis.2023.105399

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Genetic study of early-onset Parkinson's disease in the Malaysian population.

Parkinsonism & related disorders - 1 Jun 2023

Tay Yi Wen, Tan Ai Huey, Lim Jia Lun, Lohmann Katja, Ibrahim Khairul Azmi, Abdul Aziz Zariah, Chin Yen Theng, Mawardi Ahmad Shahir, Lim Thien Thien, Looi Irene, Chia Yuen Kang, Ooi Joshua Chin Ern, Cheah Wee Kooi, Dy Closas Alfand Marl F, Lit Lei Cheng, Hor Jia Wei, Toh Tzi Shin, Muthusamy Kalai Arasu, Bauer Peter, Skrahin Volha, Rolfs Arndt, Klein Christine, Ahmad-Annuar Azlina, Lim Shen-Yang

Abstract excerpt

BACKGROUND: About 5-10% of Parkinson's disease (PD) cases are early onset (EOPD), with several genes implicated, including GBA1, PRKN, PINK1, and SNCA. The spectrum and frequency of mutations vary across populations and globally diverse studies are crucial to comprehensively understand the genetic architecture of PD. The ancestral diversity of Southeast Asians offers opportunities to uncover a rich PD genetics...

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PMID: 37209484
DOI: 10.1016/j.parkreldis.2023.105399

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