Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the Limbal Epithelial Stem Cell Niche

31 Oct 2023

Abstract excerpt

Purpose: Limbal epithelial stem cells (LESCs) reside within a LSC niche (LSCN). We recently identified that hyaluronan (HA) is a major constituent of the LSCN, and that HA is necessary for maintaining LESCs in the "stem cell" state, both in vitro and in vivo. Herein, we characterized the LSCN to identify key components of the HA-specific LSCN. Methods: The cornea and limbal rim were dissected from mouse corneas,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal Surgery and Treatments
Share to Ocular Surface and Contact Lens
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37906057
DOI: 10.1167/iovs.64.13.48

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the Limbal Epithelial Stem Cell NichePMID 37906057Read ↗

Hyaluronan supports the limbal stem cell phenotype during ex vivo culture.Semantic proximity Read ↗

A single cell atlas of human cornea that defines its development, limbal stem and progenitor cells and the interactions with the limbal nicheSemantic proximity Read ↗

Limbal Epithelial Stem Cells: Role of the Niche MicroenvironmentSemantic proximity Read ↗

Expression of PAX6 and Keratocyte-Characteristic Markers in Human Limbal Stromal Cells of Congenital Aniridia and Healthy Subjects, In VitroSemantic proximity Read ↗

Preferential Biological Processes in the Human Limbus by Differential Gene ProfilingSemantic proximity Read ↗

Molecular characteristics and spatial distribution of adult human corneal cell subtypesSemantic proximity Read ↗

The human limbus functions as an instructive epithelial transition zoneSemantic proximity Read ↗

A single cell transcriptome atlas reveals the heterogeneity of the healthy human cornea and identifies novel markers of the corneal limbus and stromaSemantic proximity Read ↗

Single cell transcriptomics reveals the heterogeneity of the human cornea to identify novel markers of the limbus and stromaSemantic proximity Read ↗

Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristicsSemantic proximity Read ↗

HC-HA/PTX3 from amniotic membrane reverts senescent limbal niche cells to Pax6+ neural crest progenitors to support limbal epithelial progenitorsSemantic proximity Read ↗

Single nuclei transcriptomics of the in situ human limbal stem cell nicheSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.