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Article

Hyaluronan supports the limbal stem cell phenotype during ex vivo culture.

Stem cell research & therapy - 30 Jul 2022

Puri Sudan, Moreno Isabel Y, Sun Mingxia, Verma Sudhir, Lin Xiao, Gesteira Tarsis F, Coulson-Thomas Vivien J

Abstract excerpt

BACKGROUND: Hyaluronan (HA) has previously been identified as an integral component of the limbal stem cell niche in vivo. In this study, we investigated whether a similar HA matrix is also expressed in vitro providing a niche supporting limbal epithelial stem cells (LESCs) during ex vivo expansion. We also investigated whether providing exogenous HA in vitro is beneficial to LESCs during ex vivo expansion....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 35907870
DOI: 10.1186/s13287-022-03084-8
PMCID: PMC9338506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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