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Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity

5 Feb 2021

Abstract excerpt

While biomolecular condensates have emerged as an important biological phenomenon, mechanisms regulating their composition and the ways that viruses hijack these mechanisms remain unclear. The mosquito-borne alphaviruses cause a range of diseases from rashes and arthritis to encephalitis, and no licensed drugs are available for treatment or vaccines for prevention. The alphavirus virulence factor nonstructural...

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PMID: 33547245
DOI: 10.1073/pnas.2021719118

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