Article
Functional loss of tumor suppressor genes detected by loss of heterozygosity, but not driver mutations, predicts aggressive lymph node status in papillary thyroid carcinoma.
Pathology, research and practice - 1 Nov 2023
Finkelstein Sydney, Timmaraju Venkata Arun, Samankan Shabnam, O'Malley Quinn, Kapustin Danielle, Spaulding Sarah, Xing Monica, Matloob Ammar, Beute John, Seo Gabriella, Saturno Michael, Greenberg Lily, Wein Lauren, Gonzalez-Velazquez Camilo, Doyle Scott, Levine Jonathan, Urken Mark, Brandwein-Weber Margaret
Abstract excerpt
BACKGROUND: Recognizing aggressive tumor biology is essential to optimizing patient management for papillary thyroid carcinomas (PTC). Aggressive lymph node (ALN) status is one feature that influences decision-making. We evaluated genomic deletions in regions of tumor suppressor genes, detected by loss of heterozygosity (LOH) analysis, to understand causal alterations linked to thyroid cancer aggressiveness and...
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