Article
Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
Nature genetics - 12 Jun 2011
Chasman Daniel I, Schürks Markus, Anttila Verneri, de Vries Boukje, Schminke Ulf, Launer Lenore J, Terwindt Gisela M, van den Maagdenberg Arn M J M, Fendrich Konstanze, Völzke Henry, Ernst Florian, Griffiths Lyn R, Buring Julie E, Kallela Mikko, Freilinger Tobias, Kubisch Christian, Ridker Paul M, Palotie Aarno, Ferrari Michel D, Hoffmann Wolfgang, Zee Robert Y L, Kurth Tobias
Abstract excerpt
Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5...
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