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Article

Depression-like phenotypes in mice with hepatic ischemia/reperfusion injury: A role of gut-microbiota-liver-brain axis via vagus nerve.

Journal of affective disorders - 15 Jan 2024

Yang Yong, Eguchi Akifumi, Wan Xiayun, Mori Chisato, Hashimoto Kenji

Abstract excerpt

Depression is a frequent symptom in patients with chronic liver disease; however, the mechanisms underlying this association remain unclear. Dysbiosis of gut microbiota plays a critical role in depression through the gut-brain axis via the vagus nerve. In this study, we investigated whether the gut-microbiota-liver-brain axis plays a role in depression-like phenotypes in mice with hepatic ischemia/reperfusion...

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Identifiers

PMID: 37879416
DOI: 10.1016/j.jad.2023.10.142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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