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Article

SETD2 mutations do not contribute to clonal fitness in response to chemotherapy in childhood B cell acute lymphoblastic leukemia.

Leukemia & lymphoma - 1 Jan 2024

Contreras Yametti Gloria P, Robbins Gabriel, Chowdhury Ashfiyah, Narang Sonali, Ostrow Talia H, Kilberg Harrison, Greenberg Joshua, Kramer Lindsay, Raetz Elizabeth, Tsirigos Aristotelis, Evensen Nikki A, Carroll William L

Abstract excerpt

Mutations in genes encoding epigenetic regulators are commonly observed at relapse in B cell acute lymphoblastic leukemia (B-ALL). Loss-of-function mutations in SETD2, an H3K36 methyltransferase, have been observed in B-ALL and other cancers. Previous studies on mutated SETD2 in solid tumors and acute myelogenous leukemia support a role in promoting resistance to DNA damaging agents. We did not observe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37874744
DOI: 10.1080/10428194.2023.2273752
PMCID: PMC11874253

Genes

SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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