Article
Idiosyncratic and dose-dependent epistasis drives variation in tomato fruit size.
Science (New York, N.Y.) - 20 Oct 2023
Aguirre Lyndsey, Hendelman Anat, Hutton Samuel F, McCandlish David M, Lippman Zachary B
Abstract excerpt
Epistasis between genes is traditionally studied with mutations that eliminate protein activity, but most natural genetic variation is in cis-regulatory DNA and influences gene expression and function quantitatively. In this study, we used natural and engineered cis-regulatory alleles in a plant stem-cell circuit to systematically evaluate epistatic relationships controlling tomato fruit size. Combining a...
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