Article
Specific genetic aberrations of parathyroid in Chinese patients with tertiary hyperparathyroidism using whole-exome sequencing.
Frontiers in endocrinology - 1 Jan 2023
Li Lei, Sheng Qixuan, Zeng Huajin, Li Wei, Wang Qiang, Ma Guanjun, Xu Xinyun, Qiu Ming, Zhang Wei, Shan Chengxiang
Abstract excerpt
Background: Tertiary hyperparathyroidism (THPT) is a peculiar subtype of hyperparathyroidism that usually develops from chronic kidney disease (CKD) and persists even after kidney transplantation. Unlike its precursor, secondary hyperparathyroidism (SHPT), THPT is characterized by uncontrolled high levels of calcium in the blood, which suggests the monoclonal or oligoclonal proliferation of parathyroid cells....
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