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MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1

18 Oct 2023

Abstract excerpt

Mesenchymal stem cell (MSC)-based therapy has emerged as a promising treatment for spinal cord injury (SCI), but improving the neurogenic potential of MSCs remains a challenge. Mixed lineage leukemia 1 (MLL1), an H3K4me3 methyltransferases, plays a critical role in regulating lineage-specific gene expression and influences neurogenesis. In this study, we investigated the role and mechanism of MLL1 in the...

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PMID: 37852994
DOI: 10.1038/s41368-023-00253-0

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