Article
Fitness cost associated with cell phenotypic switching drives population diversification dynamics and controllability.
Nature communications - 2 Oct 2023
Henrion Lucas, Martinez Juan Andres, Vandenbroucke Vincent, Delvenne Mathéo, Telek Samuel, Zicler Andrew, Grünberger Alexander, Delvigne Frank
Abstract excerpt
Isogenic cell populations can cope with stress conditions by switching to alternative phenotypes. Even if it can lead to increased fitness in a natural context, this feature is typically unwanted for a range of applications (e.g., bioproduction, synthetic biology, and biomedicine) where it tends to make cellular response unpredictable. However, little is known about the diversification profiles that can be...
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