Article
An observation method for autonomous signaling-mediated synthetic diversification in Escherichia coli.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Sekine Ryoji, Ayukawa Shotaro, Kiga Daisuke
Abstract excerpt
Phenotypic diversification of cells in development and regeneration is conceptually modeled by the motion of marbles rolling down valleys on the Waddington landscape, the main feature of which is bifurcations of the valleys. We have experimentally shown that this feature is sufficient to achieve phenotypic diversification by the construction of a synthetic phenotypic diversification system in Escherichia coli....
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