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Article

Mechanisms of Regulation of the CHRDL1 Gene by the TWIST2 and ADD1/SREBP1c Transcription Factors.

Genes - 30 Aug 2023

Casasnovas-Nieves José J, Rodríguez Yacidzohara, Franco Hector L, Cadilla Carmen L

Abstract excerpt

Setleis syndrome (SS) is a rare focal facial dermal dysplasia caused by recessive mutations in the basic helix-loop-helix (bHLH) transcription factor, TWIST2. Expression microarray analysis showed that the chordin-like 1 (CHRDL1) gene is up-regulated in dermal fibroblasts from three SS patients with the Q119X TWIST2 mutation. METHODS: Putative TWIST binding sites were found in the upstream region of the CHRDL1...

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Source

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Identifiers

PMID: 37761873
DOI: 10.3390/genes14091733
PMCID: PMC10530651

Genes

TWIST2
ADD1
CHRDL1
TWIST1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mechanisms of Regulation of the CHRDL1 Gene by the TWIST2 and ADD1/SREBP1c Transcription Factors.PMID 37761873Read ↗

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Homozygous nonsense mutations in TWIST2 cause Setleis syndrome.Semantic proximity Read ↗

Setleis syndrome in Mexican-Nahua sibs due to a homozygous TWIST2 frameshift mutation and partial expression in heterozygotes: review of the focal facial dermal dysplasias and subtype reclassification.Semantic proximity Read ↗

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<i>HDAC9</i> structural variants disrupting <i>TWIST1</i> transcriptional regulation lead to craniofacial and limb malformationsSemantic proximity Read ↗

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