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Article

Beyond genome-wide association studies: Investigating the role of noncoding regulatory elements in primary sclerosing cholangitis.

Hepatology communications - 1 Oct 2023

Pratt Henry E, Wu Tong, Elhajjajy Shaimae, Zhou Jeffrey, Fitzgerald Kate, Fazzio Tom, Weng Zhiping, Pratt Daniel S

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified 30 risk loci for primary sclerosing cholangitis (PSC). Variants within these loci are found predominantly in noncoding regions of DNA making their mechanisms of conferring risk hard to define. Epigenomic studies have shown noncoding variants broadly impact regulatory element activity. The possible association of noncoding PSC variants with...

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PMID: 37756045
DOI: 10.1097/HC9.0000000000000242
PMCID: PMC10531193

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CD4

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