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Article

Genetic polymorphisms in Nrf2 and FoxO1: implications for antioxidant enzyme activity in diabetes.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Kadam Dipak A, Kalamkar Saurabh, Gajjar Vijay, Divate Uma, Karandikar-Iyer Sucheta, Ghaskadbi Saroj, Ashma Richa

Abstract excerpt

In diabetes, persistent hyperglycemia generates excess reactive oxygen species (ROS), leading to oxidative stress (OS). In response to OS, transcription factors (TFs) Nrf2 and FoxO1 get activated, which induce the expression of antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD). It is well documented that the antioxidant response in diabetic individuals is very low. Since Nrf2 and FoxO1 are the...

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Antioxidants
Catalase
Diabetes Mellitus
Forkhead Box Protein O1
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NF-E2-Related Factor 2

Oxidative Stress

Superoxide Dismutase

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PMID: 37753733
DOI: 10.1080/07391102.2023.2262580

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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