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Article

Combined deficient response to polysaccharide-based and protein-based vaccines predicts a severe clinical phenotype.

Clinical chemistry and laboratory medicine - 26 Jan 2024

Cockx Maaike, Haerynck Filomeen, Hoste Levi, Schrijvers Rik, Van der Werff Ten Bosch Jutte, Dillaerts Doreen, Thomas Debby, Schaballie Heidi, Bucciol Giorgia, Robberechts Wiert, Patel Dina, Berbers Guy, Desombere Isabelle, Geukens Nick, Meyts Isabelle, Bossuyt Xavier

Abstract excerpt

OBJECTIVES: Antibody response on polysaccharide- and protein-based vaccines is useful to test B cell functionality. As only few studies have explored the value of studying immune response to both vaccines, we evaluated the clinical value of anti-polysaccharide and anti-protein Luminex-based multiplex assays in context of primary immunodeficiency (PID) diagnosis. METHODS: A 10-plex Luminex-based assay detecting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37731388
DOI: 10.1515/cclm-2023-0626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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