Article
Distinct regions of the kinesin-5 C-terminal tail are essential for mitotic spindle midzone localization and sliding force.
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2023
Gergely Zachary R, Jones Michele H, Zhou Bojun, Cash Cai, McIntosh J Richard, Betterton Meredith D
Abstract excerpt
Kinesin-5 motor proteins play essential roles during mitosis in most organisms. Their tetrameric structure and plus-end-directed motility allow them to bind to and move along antiparallel microtubules, thereby pushing spindle poles apart to assemble a bipolar spindle. Recent work has shown that the C-terminal tail is particularly important to kinesin-5 function: The tail affects motor domain structure, ATP...
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