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Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis

13 Sept 2023

Abstract excerpt

BACKGROUND: Asthenozoospermia is the primary cause of male infertility; however, its genetic aetiology remains poorly understood. Adenylate kinase 9 (AK9) is highly expressed in the testes of humans and mice and encodes a type of adenosine kinase that is functionally involved in cellular nucleotide homeostasis and energy metabolism. We aimed to assess whether AK9 is involved in asthenozoospermia. METHODS:...

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PMID: 37713809
DOI: 10.1016/j.ebiom.2023.104798

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