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Article

Down-regulated let-7b-5p represses glycolysis metabolism by targeting AURKB in asthenozoospermia.

Gene - 15 Jul 2018

Zhou Ran, Zhang Yan, Du Guizhen, Han Li, Zheng Sinian, Liang Jian, Huang Xiaomin, Qin Yufeng, Wu Wei, Chen Minjian, Wu Di, Song Ling, Fu Guangbo, Lv Shuyan, Xia Yankai, Lu Chuncheng, Wang Xinru

Abstract excerpt

Glycolysis, through anaerobic respiration, can supply energy for human sperm motility. MicroRNAs (miRNAs) could participate in the glycolytic pathway through regulating target genes. To investigate the potential role of glycolysis-related miRNAs in asthenozoospermia, TaqMan Low Density Array (TLDA) was used to screen potentially functional miRNAs, and seven glycolysis-related miRNAs were isolated to be related to...

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Identifiers

PMID: 29653228
DOI: 10.1016/j.gene.2018.04.022

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AURKB

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