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Article

Single-cell transcriptome analysis reveals dynamic changes of the preclinical A549 cancer models, and the mechanism of dacomitinib.

European journal of pharmacology - 5 Dec 2023

Chen Xiaoyan, Yu Yangziwei, Zheng Haoyang, Yang Mengjing, Wang Chuqiao, Cai Qianqian, Zhang Weiguo, Jiang Feixiang, Zhu Yanmei, Yang Hedi, Zhang Tianbiao, Zhou Zhaoli

Abstract excerpt

The in vitro A549 cells, and A549 xenografts in nude mouse, were two commonly used models for anti-cancer drug discovery. However, the biological and molecular characteristics of these two classic models, and also the dynamic transcriptome changes after dacomitinib exposure remains elusive. We performed single-cell RNA sequencing to define the transcriptome profile at single-cell resolution, and processed tumor...

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PMID: 37708985
DOI: 10.1016/j.ejphar.2023.176046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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