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Article

IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels

14 Sept 2023

Abstract excerpt

Abstract Rationale IL-33 is a proinflammatory cytokine thought to play a role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). A recent clinical trial using an anti–IL-33 antibody showed a reduction in exacerbation and improved lung function in ex-smokers but not current smokers with COPD. Objectives This study aimed to understand the effects of smoking status on IL-33. Methods We...

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PMID: 37708400
DOI: 10.1164/rccm.202210-1881oc

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