Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case-Control Study.

doi:10.1016/j.ebiom.2016.02.014

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Article

Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case-Control Study.

EBioMedicine - 1 Mar 2016

Xu Zhi-Peng, Yang Su-Lian, Zhao Shi, Zheng Cheng-Hong, Li Hong-Hua, Zhang Yao, Huang Rong-Xi, Li Meng-Zhu, Gao Yuan, Zhang Shu-Juan, Zhan Pei-Yan, Zhang Li-Fang, Deng Lin, Wei Sheng, Liu Yan-Chao, Ye Jing-Wang, Ren Hu-Jun, Li Na, Kong Cai-Xia, Wang Xin, Fang Lin, Zhou Qiu-Zhi, Jiang Hong-Wei, Li Jing-Rong, Wang Qun, Ke Dan, Liu Gong-Ping, Wang Jian-Zhi

Abstract excerpt

BACKGROUND: Both type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are common age-associated disorders and T2DM patients show an increased risk to suffer from AD, however, there is currently no marker to identify who in T2DM populations will develop AD. Since glycogen synthase kinase-3β (GSK-3β) activity, ApoE genotypes and olfactory function are involved in both T2DM and AD pathogenesis, we...

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PMID: 27077117
DOI: 10.1016/j.ebiom.2016.02.014
PMCID: PMC4816853

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