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Article

Insights into the catalytic mechanism of Grimontia hollisae collagenase through structural and mutational analyses.

FEBS letters - 1 Oct 2023

Ueshima Saori, Yasumoto Mizuki, Kitagawa Yuto, Akazawa Kaho, Takita Teisuke, Tanaka Keisuke, Hattori Shunji, Mizutani Kimihiko, Mikami Bunzo, Yasukawa Kiyoshi

Abstract excerpt

Grimontia hollisae collagenase (Ghcol) exhibits high collagen-degrading activity. To explore its catalytic mechanism, its substrate (Gly-Pro-Hyp-Gly-Pro-Hyp, GPOGPO)-complexed crystal structure was determined at 2.0 Å resolution. A water molecule was observed near the active-site zinc ion. Since this water was not observed in the product (GPO)-complexed Ghcol, it was hypothesized that the GPOGPO-complexed Ghcol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37698340
DOI: 10.1002/1873-3468.14732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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