Article
In silico analysis of non-structural protein 12 sequences from SARS-COV-2 found in Manaus, Amazonas, Brazil, reveals mutations linked to higher transmissibility.
Anais da Academia Brasileira de Ciencias - 1 Jan 2024
Zanchi Fernando B, Ferreira Gabriel Eduardo M, Mariúba Luis André M, Glória Juliane C, Nascimento Valdinete A DO, Souza Victor C DE, Corado André DE Lima G, Nascimento Fernanda O DO, Costa Ágatha Kélly A DA, Duarte Débora Camila G, Silva George Allan V DA, Mejía Matilde Del Carmen C, Pessoa Karina P, Gonçalves Luciana Mara F, Brandão Maria Júlia P, Jesus Michele S DE, Silva Marineide S DA, Costa Cristiano F DA, Naveca Felipe G
Abstract excerpt
The disease coronavirus COVID-19 has been the cause of millions of deaths worldwide. Among the proteins of SARS-CoV-2, non-structural protein 12 (NSP12) plays a key role during COVID infection and is part of the RNA-dependent RNA polymerase complex. The monitoring of NSP12 polymorphisms is extremely important for the design of new antiviral drugs and monitoring of viral evolution. This study analyzed the NSP12...
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