Article
Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study.
PLoS medicine - 1 Jan 2019
Budu-Aggrey Ashley, Brumpton Ben, Tyrrell Jess, Watkins Sarah, Modalsli Ellen H, Celis-Morales Carlos, Ferguson Lyn D, Vie Gunnhild Åberge, Palmer Tom, Fritsche Lars G, Løset Mari, Nielsen Jonas Bille, Zhou Wei, Tsoi Lam C, Wood Andrew R, Jones Samuel E, Beaumont Robin, Saunes Marit, Romundstad Pål Richard, Siebert Stefan, McInnes Iain B, Elder James T, Davey Smith George, Frayling Timothy M, Åsvold Bjørn Olav, Brown Sara J, Sattar Naveed, Paternoster Lavinia
Abstract excerpt
BACKGROUND: Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis. METHODS AND FINDINGS: Following a review of published epidemiological evidence of the association between obesity and psoriasis, mendelian randomization (MR) was used to test for a causal relationship...
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