Characteristics and clinical outcomes of patients with myeloid malignancies and DDX41 variants.

doi:10.1002/ajh.27070

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Article

Characteristics and clinical outcomes of patients with myeloid malignancies and DDX41 variants.

American journal of hematology - 1 Nov 2023

Bataller Alex, Loghavi Sanam, Gerstein Yoheved, Bazinet Alexandre, Sasaki Koji, Chien Kelly S, Hammond Danielle, Montalban-Bravo Guillermo, Borthakur Gautam, Short Nicholas, Issa Ghayas C, Kadia Tapan M, Daver Naval, Tang Guilin, Quesada Andres, Patel Keyur P, Ravandi Farhad, Fiskus Warren, Mill Cristopher P, Kantarjian Hagop M, Bhalla Kapil, Garcia-Manero Guillermo, Oran Betul, DiNardo Courtney D

Abstract excerpt

DDX41 is the most frequently mutated gene in myeloid neoplasms associated with germline predisposition including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We analyzed 3795 patients with myeloid neoplasms and identified 151 (4%) with DDX41 variants and a diagnosis of AML (n = 96), MDS (n = 52), and chronic myelomonocytic leukemia (n = 3). The most frequent DDX41 variants were the somatic...

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PMID: 37665752
DOI: 10.1002/ajh.27070

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