Article
Comparative transcriptomics of porcine liver-resident CD8αdim, liver CD8αhigh and circulating blood CD8αhigh NK cells reveals an intermediate phenotype of liver CD8αhigh NK cells.
Frontiers in immunology - 1 Jan 2023
Hermans Leen, Denaeghel Sofie, Jansens Robert J J, De Pelsmaeker Steffi, Van Nieuwerburgh Filip, Deforce Dieter, Hegewisch-Solloa Everardo, Mace Emily M, Cox Eric, Devriendt Bert, Favoreel Herman W
Abstract excerpt
Liver-resident NK (lrNK) cells have been studied in humans as well as in mice. Unfortunately, important differences have been observed between murine and human lrNK cells, complicating the extrapolation of data obtained in mice to man. We previously described two NK cell subsets in the porcine liver: A CD8αhigh subset, with a phenotype much like conventional CD8αhigh NK cells found in the peripheral blood, and a...
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